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Titel:

The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Pechloff, K; Holch, J; Ferch, U; Schweneker, M; Brunner, K; Kremer, M; Sparwasser, T; Quintanilla-Martinez, L; Zimber-Strobl, U; Streubel, B; Gewies, A; Peschel, C; Ruland, J
Abstract:
Peripheral T cell lymphomas (PTCLs) are highly aggressive malignancies with poor prognosis. Their molecular pathogenesis is not well understood and small animal models for the disease are lacking. Recently, the chromosomal translocation t(5; 9)(q33; q22) generating the interleukin-2 (IL-2)-inducible T cell kinase (ITK)-spleen tyrosine kinase (SYK) fusion tyrosine kinase was identified as a recurrent event in PTCL. We show that ITK-SYK associates constitutively with lipid rafts in T cells and tri...     »
Zeitschriftentitel:
J Exp Med
Jahr:
2010
Band / Volume:
207
Heft / Issue:
5
Seitenangaben Beitrag:
1031-44
Sprache:
eng
Volltext / DOI:
doi:10.1084/jem.20092042
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20439541
Print-ISSN:
0022-1007
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Roman Herzog Comprehensive Cancer Center
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