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Title:

The CARMA3-Bcl10-MALT1 signalosome promotes angiotensin II-dependent vascular inflammation and atherogenesis.

Document type:
journal article
Author(s):
McAllister-Lucas, LM; Jin, X; Gu, S; Siu, K; McDonnell, S; Ruland, J; Delekta, PC; Van Beek, M; Lucas, PC
Abstract:
The CARMA1, Bcl10, and MALT1 proteins together constitute a signaling complex (CBM signalosome) that mediates antigen-dependent activation of NF-kappaB in lymphocytes, thereby representing a cornerstone of the adaptive immune response. Although CARMA1 is restricted to cells of the immune system, the analogous CARMA3 protein has a much wider expression pattern. Emerging evidence suggests that CARMA3 can substitute for CARMA1 in non-immune cells to assemble a CARMA3-Bcl10-MALT1 signalosome and med...     »
Journal title abbreviation:
J Biol Chem
Year:
2010
Journal volume:
285
Journal issue:
34
Pages contribution:
25880-4
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20605784
Print-ISSN:
0021-9258
TUM Institution:
III. Medizinische Klinik und Poliklinik
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