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Titel:

The CARMA3-Bcl10-MALT1 signalosome promotes angiotensin II-dependent vascular inflammation and atherogenesis.

Dokumenttyp:
journal article
Autor(en):
McAllister-Lucas, LM; Jin, X; Gu, S; Siu, K; McDonnell, S; Ruland, J; Delekta, PC; Van Beek, M; Lucas, PC
Abstract:
The CARMA1, Bcl10, and MALT1 proteins together constitute a signaling complex (CBM signalosome) that mediates antigen-dependent activation of NF-kappaB in lymphocytes, thereby representing a cornerstone of the adaptive immune response. Although CARMA1 is restricted to cells of the immune system, the analogous CARMA3 protein has a much wider expression pattern. Emerging evidence suggests that CARMA3 can substitute for CARMA1 in non-immune cells to assemble a CARMA3-Bcl10-MALT1 signalosome and med...     »
Zeitschriftentitel:
J Biol Chem
Jahr:
2010
Band / Volume:
285
Heft / Issue:
34
Seitenangaben Beitrag:
25880-4
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20605784
Print-ISSN:
0021-9258
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik
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