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Title:

Extracellular matrix metalloproteinase inducer (CD147) and membrane type 1-matrix metalloproteinase are expressed on tissue macrophages in calcific aortic stenosis and induce transmigration in an artificial valve model.

Document type:
Journal Article
Author(s):
Joghetaei, N; Akhyari, P; Rauch, BH; Cullen, P; Lichtenberg, A; Rudelius, M; Pelisek, J; Schmidt, R
Abstract:
Matrix metalloproteinases participate in remodeling of extracellular matrix, which is central to the development of aortic stenosis. Synthesis of certain matrix metalloproteinases is induced by the glycoprotein extracellular matrix metalloproteinase inducer. We investigated whether extracellular matrix metalloproteinase inducer and membrane-type 1 matrix metalloproteinase are abundant in calcific aortic valve and their role in the pathogenesis of this condition.Sixteen patients who underwent sur...     »
Journal title abbreviation:
J Thorac Cardiovasc Surg
Year:
2011
Journal volume:
142
Journal issue:
1
Pages contribution:
191-8
Language:
eng
Fulltext / DOI:
doi:10.1016/j.jtcvs.2010.09.051
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21146836
Print-ISSN:
0022-5223
TUM Institution:
Fachgebiet Gefäßchirurgie (Prof. Eckstein); I. Medizinische Klinik und Poliklinik (Kardiologie); Institut für Allgemeine Pathologie und Pathologische Anatomie
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