User: Guest  Login
Less Searchfields
Simple search
Title:

Identification of novel downstream targets of platelet glycoprotein VI activation by differential proteome analysis: implications for thrombus formation.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Schulz, C; Leuschen, NV; Frohlich, T; Lorenz, M; Pfeiler, S; Gleissner, CA; Kremmer, E; Kessler, M; Khandoga, AG; Engelmann, B; Ley, K; Massberg, S; Arnold, GJ
Abstract:
Platelets play a key role in hemostasis and various diseases including arterial thrombosis. Glycoprotein VI (GPVI) mediates adhesion to collagen structures exposed at sites of vascular injury and subsequent platelet activation. We determined the effects of specific activation of GPVI on the human platelet proteome. Isolated human platelets were stimulated with an activating monoclonal antibody specific for GPVI. Platelet proteins were analyzed by 2-dimensional difference gel electrophoresis (2D-...     »
Journal title abbreviation:
Blood
Year:
2010
Journal volume:
115
Journal issue:
20
Pages contribution:
4102-10
Language:
eng
Fulltext / DOI:
doi:10.1182/blood-2009-07-230268
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20107233
Print-ISSN:
0006-4971
TUM Institution:
I. Medizinische Klinik und Poliklinik (Kardiologie)
 BibTeX