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Title:

Protective effect of the CYP2C19 *17 polymorphism with increased activation of clopidogrel on cardiovascular events.

Document type:
Journal Article; Article
Author(s):
Tiroch, KA; Sibbing, D; Koch, W; Roosen-Runge, T; Mehilli, J; Schömig, A; Kastrati, A
Abstract:
The prodrug clopidogrel requires activation by cytochrome P-450 (CYP) enzymes for its antiplatelet effect. The genes encoding enzymes for clopidogrel activation are polymorphic, leading to reduced or increased function, depending on the respective genotype. Reduced-function alleles have been associated with an increase in cardiovascular events.We tested the association of the presence of the ABCB1 (C/T) T-allele, CYP2C19*2 (G/A) A-allele, or CYP2C19*17 (C/T) T-allele with the primary end point o...     »
Journal title abbreviation:
Am Heart J
Year:
2010
Journal volume:
160
Journal issue:
3
Pages contribution:
506-12
Language:
eng
Fulltext / DOI:
doi:10.1016/j.ahj.2010.06.039
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20826260
Print-ISSN:
0002-8703
TUM Institution:
I. Medizinische Klinik und Poliklinik (Kardiologie)
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