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Title:

Platelets contribute to postnatal occlusion of the ductus arteriosus.

Document type:
Journal Article; Article
Author(s):
Echtler, K; Stark, K; Lorenz, M; Kerstan, S; Walch, A; Jennen, L; Rudelius, M; Seidl, S; Kremmer, E; Emambokus, NR; von Bruehl, ML; Frampton, J; Isermann, B; Genzel-Boroviczeny, O; Schreiber, C; Mehilli, J; Kastrati, A; Schwaiger, M; Shivdasani, RA; Massberg, S
Abstract:
The ductus arteriosus (DA) is a fetal shunt vessel between the pulmonary artery and the aorta that closes promptly after birth. Failure of postnatal DA closure is a major cause of morbidity and mortality particularly in preterm neonates. The events leading to DA closure are incompletely understood. Here we show that platelets have an essential role in DA closure. Using intravital microscopy of neonatal mice, we observed that platelets are recruited to the luminal aspect of the DA during closure....     »
Journal title abbreviation:
Nat Med
Year:
2010
Journal volume:
16
Journal issue:
1
Pages contribution:
75-82
Language:
eng
Fulltext / DOI:
doi:10.1038/nm.2060
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19966813
Print-ISSN:
1078-8956
TUM Institution:
I. Medizinische Klinik und Poliklinik (Kardiologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik für Herz- und Gefäßchirurgie (Prof. Lange); Klinik und Poliklinik für Nuklearmedizin
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