Benutzer: Gast  Login
Titel:

Identification of novel downstream targets of platelet glycoprotein VI activation by differential proteome analysis: implications for thrombus formation.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Schulz, C; Leuschen, NV; Frohlich, T; Lorenz, M; Pfeiler, S; Gleissner, CA; Kremmer, E; Kessler, M; Khandoga, AG; Engelmann, B; Ley, K; Massberg, S; Arnold, GJ
Abstract:
Platelets play a key role in hemostasis and various diseases including arterial thrombosis. Glycoprotein VI (GPVI) mediates adhesion to collagen structures exposed at sites of vascular injury and subsequent platelet activation. We determined the effects of specific activation of GPVI on the human platelet proteome. Isolated human platelets were stimulated with an activating monoclonal antibody specific for GPVI. Platelet proteins were analyzed by 2-dimensional difference gel electrophoresis (2D-...     »
Zeitschriftentitel:
Blood
Jahr:
2010
Band / Volume:
115
Heft / Issue:
20
Seitenangaben Beitrag:
4102-10
Sprache:
eng
Volltext / DOI:
doi:10.1182/blood-2009-07-230268
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20107233
Print-ISSN:
0006-4971
TUM Einrichtung:
I. Medizinische Klinik und Poliklinik (Kardiologie)
 BibTeX