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Title:

A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals.

Document type:
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Nebel, A; Kleindorp, R; Caliebe, A; Nothnagel, M; Blanche, H; Junge, O; Wittig, M; Ellinghaus, D; Flachsbart, F; Wichmann, HE; Meitinger, T; Nikolaus, S; Franke, A; Krawczak, M; Lathrop, M; Schreiber, S
Abstract:
We conducted a case-control genome-wide association study (GWAS) of human longevity, comparing 664,472 autosomal SNPs in 763 long-lived individuals (LLI; mean age: 99.7 years) and 1085 controls (mean age: 60.2 years) from Germany. Only one association, namely that of SNP rs4420638 near the APOC1 gene, achieved genome-wide significance (allele-based P=1.8×10(-10)). However, logistic regression analysis revealed that this association, which was replicated in an independent German sample, is fully...     »
Journal title abbreviation:
Mech Ageing Dev
Year:
2011
Journal volume:
132
Journal issue:
6-7
Pages contribution:
324-30
Language:
eng
Fulltext / DOI:
doi:10.1016/j.mad.2011.06.008
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21740922
Print-ISSN:
0047-6374
TUM Institution:
Institut für Humangenetik
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