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Titel:

Common variants in P2RY11 are associated with narcolepsy.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Article
Autor(en):
Kornum, BR; Kawashima, M; Faraco, J; Lin, L; Rico, TJ; Hesselson, S; Axtell, RC; Kuipers, H; Weiner, K; Hamacher, A; Kassack, MU; Han, F; Knudsen, S; Li, J; Dong, X; Winkelmann, J; Plazzi, G; Nevsimalova, S; Hong, SC; Honda, Y; Honda, M; Högl, B; Ton, TG; Montplaisir, J; Bourgin, P; Kemlink, D; Huang, YS; Warby, S; Einen, M; Eshragh, JL; Miyagawa, T; Desautels, A; Ruppert, E; Hesla, PE; Poli, F; Pizza, F; Frauscher, B; Jeong, JH; Lee, SP; Strohl, KP; Longstreth, WT; Kvale, M; Dobrovolná, M; Ohay...     »
Abstract:
Growing evidence supports the hypothesis that narcolepsy with cataplexy is an autoimmune disease. We here report genome-wide association analyses for narcolepsy with replication and fine mapping across three ethnic groups (3,406 individuals of European ancestry, 2,414 Asians and 302 African Americans). We identify a SNP in the 3' untranslated region of P2RY11, the purinergic receptor subtype P2Y?? gene, which is associated with narcolepsy (rs2305795, combined P = 6.1 × 10?¹?, odds ratio = 1.28,...     »
Zeitschriftentitel:
Nat Genet
Jahr:
2011
Band / Volume:
43
Heft / Issue:
1
Seitenangaben Beitrag:
66-71
Sprache:
eng
Volltext / DOI:
doi:10.1038/ng.734
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21170044
Print-ISSN:
1061-4036
TUM Einrichtung:
Institut für Humangenetik; Neurologische Klinik und Poliklinik
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