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Titel:

Identification of recurring tumor-specific somatic mutations in acute myeloid leukemia by transcriptome sequencing.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Greif, PA; Eck, SH; Konstandin, NP; Benet-Pagès, A; Ksienzyk, B; Dufour, A; Vetter, AT; Popp, HD; Lorenz-Depiereux, B; Meitinger, T; Bohlander, SK; Strom, TM
Abstract:
Genetic lesions are crucial for cancer initiation. Recently, whole genome sequencing, using next generation technology, was used as a systematic approach to identify mutations in genomes of various types of tumors including melanoma, lung and breast cancer, as well as acute myeloid leukemia (AML). Here, we identify tumor-specific somatic mutations by sequencing transcriptionally active genes. Mutations were detected by comparing the transcriptome sequence of an AML sample with the corresponding...     »
Zeitschriftentitel:
Leukemia
Jahr:
2011
Band / Volume:
25
Heft / Issue:
5
Seitenangaben Beitrag:
821-7
Sprache:
eng
Volltext / DOI:
doi:10.1038/leu.2011.19
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21339757
Print-ISSN:
0887-6924
TUM Einrichtung:
Institut für Humangenetik
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