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Titel:

Human metabolic individuality in biomedical and pharmaceutical research.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; nicht gelistet
Autor(en):
Suhre, K; Shin, SY; Petersen, AK; Mohney, RP; Meredith, D; Wägele, B; Altmaier, E; Deloukas, P; Erdmann, J; Grundberg, E; Hammond, CJ; de Angelis, MH; Kastenmüller, G; Köttgen, A; Kronenberg, F; Mangino, M; Meisinger, C; Meitinger, T; Mewes, HW; Milburn, MV; Prehn, C; Raffler, J; Ried, JS; Römisch-Margl, W; Samani, NJ; Small, KS; Wichmann, HE; Zhai, G; Illig, T; Spector, TD; Adamski, J; Soranzo, N; Gieger, C
Abstract:
Genome-wide association studies (GWAS) have identified many risk loci for complex diseases, but effect sizes are typically small and information on the underlying biological processes is often lacking. Associations with metabolic traits as functional intermediates can overcome these problems and potentially inform individualized therapy. Here we report a comprehensive analysis of genotype-dependent metabolic phenotypes using a GWAS with non-targeted metabolomics. We identified 37 genetic loci as...     »
Zeitschriftentitel:
Nature
Jahr:
2011
Band / Volume:
477
Heft / Issue:
7362
Seitenangaben Beitrag:
54-60
Sprache:
eng
Volltext / DOI:
doi:10.1038/nature10354
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21886157
Print-ISSN:
0028-0836
TUM Einrichtung:
Institut für Humangenetik
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