Association of early repolarization pattern on ECG with risk of cardiac and all-cause mortality: a population-based prospective cohort study (MONICA/KORA).

Sinner, MF; Reinhard, W; Muller, M; Beckmann, BM; Martens, E; Perz, S; Pfeufer, A; Winogradow, J; Stark, K; Meisinger, C; Wichmann, HE; Peters, A; Riegger, GA; Steinbeck, G; Hengstenberg, C; Kääb, S

doi:10.1371/journal.pmed.1000314

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Title:: Association of early repolarization pattern on ECG with risk of cardiac and all-cause mortality: a population-based prospective cohort study (MONICA/KORA).
Document type:: Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):: Sinner, MF; Reinhard, W; Muller, M; Beckmann, BM; Martens, E; Perz, S; Pfeufer, A; Winogradow, J; Stark, K; Meisinger, C; Wichmann, HE; Peters, A; Riegger, GA; Steinbeck, G; Hengstenberg, C; Kääb, S
Abstract:: Early repolarization pattern (ERP) on electrocardiogram was associated with idiopathic ventricular fibrillation and sudden cardiac arrest in a case-control study and with cardiovascular mortality in a Finnish community-based sample. We sought to determine ERP prevalence and its association with cardiac and all-cause mortality in a large, prospective, population-based case-cohort study (Monitoring of Cardiovascular Diseases and Conditions [MONICA]/KORA [Cooperative Health Research in the Region of Augsburg]) comprised of individuals of Central-European descent.Electrocardiograms of 1,945 participants aged 35-74 y, representing a source population of 6,213 individuals, were analyzed applying a case-cohort design. Mean follow-up was 18.9 y. Cause of death was ascertained by the 9th revision of the International Classification of Disease (ICD-9) codes as documented in death certificates. ERP-attributable effects on mortality were determined by a weighted Cox proportional hazard model adjusted for covariables. Prevalence of ERP was 13.1% in our study. ERP was associated with cardiac and all-cause mortality, most pronounced in those of younger age and male sex; a clear ERP-age interaction was detected (p = 0.005). Age-stratified analyses showed hazard ratios (HRs) for cardiac mortality of 1.96 (95% confidence interval [CI] 1.05-3.68, p = 0.035) for both sexes and 2.65 (95% CI 1.21-5.83, p = 0.015) for men between 35-54 y. An inferior localization of ERP further increased ERP-attributable cardiac mortality to HRs of 3.15 (95% CI 1.58-6.28, p = 0.001) for both sexes and to 4.27 (95% CI 1.90-9.61, p<0.001) for men between 35-54 y. HRs for all-cause mortality were weaker but reached significance.We found a high prevalence of ERP in our population-based cohort of middle-aged individuals. ERP was associated with about a 2- to 4-fold increased risk of cardiac mortality in individuals between 35 and 54 y. An inferior localization of ERP was associated with a particularly increased risk. Please see later in the article for the Editors' Summary.
Journal title abbreviation:: PLoS Med
Year:: 2010
Journal volume:: 7
Journal issue:: 7
Pages contribution:: e1000314
Language:: eng
Fulltext / DOI:: doi:10.1371/journal.pmed.1000314
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/20668657
Print-ISSN:: 1549-1277
TUM Institution:: Institut für Humangenetik
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mediaTUM Gesamtbestand Hochschulbibliographie 2010 Fakultäten Medizin Institut für Humangenetik

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Institut für Humangenetik (Prof. Winkelmann)2010