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Title:

Tumor necrosis factor-? enhances microvascular tone and reduces blood flow in the cochlea via enhanced sphingosine-1-phosphate signaling.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Scherer, EQ; Yang, J; Canis, M; Reimann, K; Ivanov, K; Diehl, CD; Backx, PH; Wier, WG; Strieth, S; Wangemann, P; Voigtlaender-Bolz, J; Lidington, D; Bolz, SS
Abstract:
We sought to demonstrate that tumor necrosis factor (TNF)-?, via sphingosine-1-phosphate signaling, has the potential to alter cochlear blood flow and thus, cause ischemic hearing loss.We performed intravital fluorescence microscopy to measure blood flow and capillary diameter in anesthetized guinea pigs. To measure capillary diameter ex vivo, capillary beds from the gerbil spiral ligament were isolated from the cochlear lateral wall and maintained in an organ bath. Isolated gerbil spiral modiol...     »
Journal title abbreviation:
Stroke
Year:
2010
Journal volume:
41
Journal issue:
11
Pages contribution:
2618-24
Language:
eng
Fulltext / DOI:
doi:10.1161/STROKEAHA.110.593327
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20930159
Print-ISSN:
0039-2499
TUM Institution:
Hals-Nasen-Ohrenklinik und Poliklinik
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