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Titel:

C-terminus of heat shock protein 70-interacting protein-dependent GTP cyclohydrolase I degradation in lambs with increased pulmonary blood flow.

Dokumenttyp:
Journal Article; Article
Autor(en):
Sun, X; Fratz, S; Sharma, S; Hou, Y; Rafikov, R; Kumar, S; Rehmani, I; Tian, J; Smith, A; Schreiber, C; Reiser, J; Naumann, S; Haag, S; Hess, J; Catravas, JD; Patterson, C; Fineman, JR; Black, SM
Abstract:
We showed that nitric oxide (NO) signaling is decreased in the pulmonary vasculature before the development of endothelial dysfunction in a lamb model of congenital heart disease and increased pulmonary blood flow (Shunt). The elucidation of the molecular mechanism by which this occurs was the purpose of this study. Here, we demonstrate that concentrations of the endogenous NO synthase (NOS) inhibitor, asymmetric dimethylarginine (ADMA), are elevated, whereas the NOS cofactor tetrahydrobiopterin...     »
Zeitschriftentitel:
Am J Respir Cell Mol Biol
Jahr:
2011
Band / Volume:
45
Heft / Issue:
1
Seitenangaben Beitrag:
163-71
Sprache:
eng
Volltext / DOI:
doi:10.1165/rcmb.2009-0467OC
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20870896
Print-ISSN:
1044-1549
TUM Einrichtung:
Klinik für Herz- und Gefäßchirurgie (Prof. Lange); Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess)
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