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Title:

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Massberg, S; Grahl, L; von Bruehl, ML; Manukyan, D; Pfeiler, S; Goosmann, C; Brinkmann, V; Lorenz, M; Bidzhekov, K; Khandagale, AB; Konrad, I; Kennerknecht, E; Reges, K; Holdenrieder, S; Braun, S; Reinhardt, C; Spannagl, M; Preissner, KT; Engelmann, B
Abstract:
Blood neutrophils provide the first line of defense against pathogens but have also been implicated in thrombotic processes. This dual function of neutrophils could reflect an evolutionarily conserved association between blood coagulation and antimicrobial defense, although the molecular determinants and in vivo significance of this association remain unclear. Here we show that major microbicidal effectors of neutrophils, the serine proteases neutrophil elastase and cathepsin G, together with ex...     »
Journal title abbreviation:
Nat Med
Year:
2010
Journal volume:
16
Journal issue:
8
Pages contribution:
887-96
Language:
eng
Fulltext / DOI:
doi:10.1038/nm.2184
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20676107
Print-ISSN:
1078-8956
TUM Institution:
I. Medizinische Klinik und Poliklinik (Kardiologie); Institut für Laboratoriumsmedizin (keine SAP-Zuordnung!)
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