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Titel:

Quercetin protects primary human osteoblasts exposed to cigarette smoke through activation of the antioxidative enzymes HO-1 and SOD-1.

Dokumenttyp:
Journal Article; Article
Autor(en):
Braun, KF; Ehnert, S; Freude, T; Egana, JT; Schenck, TL; Buchholz, A; Schmitt, A; Siebenlist, S; Schyschka, L; Neumaier, M; Stöckle, U; Nüssler, AK
Abstract:
Smokers frequently suffer from impaired fracture healing often due to poor bone quality and stability. Cigarette smoking harms bone cells and their homeostasis by increased formation of reactive oxygen species (ROS). The aim of this study was to investigate whether Quercetin, a naturally occurring antioxidant, can protect osteoblasts from the toxic effects of smoking. Human osteoblasts exposed to cigarette smoke medium (CSM) rapidly produced ROS and their viability decreased concentration- and t...     »
Zeitschriftentitel:
ScientificWorldJournal
Jahr:
2011
Band / Volume:
11
Seitenangaben Beitrag:
2348-57
Sprache:
eng
Volltext / DOI:
doi:10.1100/2011/471426
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22203790
TUM Einrichtung:
Klinik und Poliklinik für Unfallchirurgie; Lehrstuhl für Plastische Chirurgie und Handchirurgie (Prof. Machens)
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