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Title:

Vascular endothelial growth factor (VEGF165) plus basic fibroblast growth factor (bFGF) producing cells induce a mature and stable vascular network--a future therapy for ischemically challenged tissue.

Document type:
Journal Article
Author(s):
Spanholtz, TA; Theodorou, P; Holzbach, T; Wutzler, S; Giunta, RE; Machens, HG
Abstract:
Vascular endothelial growth factor (VEGF)(165) induces formation of immature blood vessels with increased permeability. In this study, we used a cell-based gene-transfer model of fibroblasts to investigate the effects of a combined in vivo treatment consisting of the VEGF165 and basic fibroblast growth factor (bFGF) proteins on ischemic and non-ischemic tissues.After controlled in vitro adenoviral transfection we transplanted fibroblasts into either healthy tissue, or into an ischemic skin flap...     »
Journal title abbreviation:
J Surg Res
Year:
2011
Journal volume:
171
Journal issue:
1
Pages contribution:
329-38
Language:
eng
Fulltext / DOI:
doi:10.1016/j.jss.2010.03.033
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20605609
Print-ISSN:
0022-4804
TUM Institution:
Lehrstuhl für Plastische Chirurgie und Handchirurgie (Prof. Machens)
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