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Titel:

Use of gene-modified keratinocytes and fibroblasts to enhance regeneration in a full skin defect.

Dokumenttyp:
Journal Article
Autor(en):
Lohmeyer, JA; Liu, F; Krüger, S; Lindenmaier, W; Siemers, F; Machens, HG
Abstract:
With the development of cell-based gene transfer techniques, genetically modified human keratinocytes (Kc) and fibroblasts (Fb) have been proven to be a better choice in wound repair.This study was designed to construct in one step a gene-modified artificial skin by a genetically engineered Kc expressing PDGF-BB and Fb expressing VEGF(165) and bFGF. The wound healing effect in a full-thickness wound model was then observed. Unmodified artificial skin served as control. On the post-operative days...     »
Zeitschriftentitel:
Langenbecks Arch Surg
Jahr:
2011
Band / Volume:
396
Heft / Issue:
4
Seitenangaben Beitrag:
543-50
Sprache:
eng
Volltext / DOI:
doi:10.1007/s00423-011-0761-3
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21369846
Print-ISSN:
1435-2443
TUM Einrichtung:
Lehrstuhl für Plastische Chirurgie und Handchirurgie (Prof. Machens)
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