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Titel:

Control of bone formation by the serpentine receptor Frizzled-9.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Albers, J; Schulze, J; Beil, FT; Gebauer, M; Baranowsky, A; Keller, J; Marshall, RP; Wintges, K; Friedrich, FW; Priemel, M; Schilling, AF; Rueger, JM; Cornils, K; Fehse, B; Streichert, T; Sauter, G; Jakob, F; Insogna, KL; Pober, B; Knobeloch, KP; Francke, U; Amling, M; Schinke, T
Abstract:
Although Wnt signaling in osteoblasts is of critical importance for the regulation of bone remodeling, it is not yet known which specific Wnt receptors of the Frizzled family are functionally relevant in this process. In this paper, we show that Fzd9 is induced upon osteoblast differentiation and that Fzd9(-/-) mice display low bone mass caused by impaired bone formation. Our analysis of Fzd9(-/-) primary osteoblasts demonstrated defects in matrix mineralization in spite of normal expression of...     »
Zeitschriftentitel:
J Cell Biol
Jahr:
2011
Band / Volume:
192
Heft / Issue:
6
Seitenangaben Beitrag:
1057-72
Sprache:
eng
Volltext / DOI:
doi:10.1083/jcb.201008012
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21402791
Print-ISSN:
0021-9525
TUM Einrichtung:
Lehrstuhl für Plastische Chirurgie und Handchirurgie (Prof. Machens)
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