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Title:

Magnetically guided lentiviral-mediated transduction of airway epithelial cells.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Orlando, C; Castellani, S; Mykhaylyk, O; Copreni, E; Zelphati, O; Plank, C; Conese, M
Abstract:
Lentiviral (LV) vectors are able to only slowly and inefficiently transduce nondividing cells such as those of the airway epithelium. To address this issue, we have exploited the magnetofection technique in in vitro models of airway epithelium.Magnetofectins were formed by noncovalent interaction between LV particles and polycation-coated iron oxide nanoparticles. Efficiency of LV-mediated transduction (as evaluated through green fluorescent protein (GFP) expression by cytofluorimetric analysis)...     »
Journal title abbreviation:
J Gene Med
Year:
2010
Journal volume:
12
Journal issue:
9
Pages contribution:
747-54
Language:
eng
Fulltext / DOI:
doi:10.1002/jgm.1494
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20821745
Print-ISSN:
1099-498X
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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