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Title:

Tetracycline-regulated bone morphogenetic protein 2 gene expression in lentivirally transduced primary rabbit chondrocytes for treatment of cartilage defects.

Document type:
Journal Article
Author(s):
Wübbenhorst, D; Dumler, K; Wagner, B; Wexel, G; Imhoff, A; Gansbacher, B; Vogt, S
Abstract:
Treatment of cartilage defects is still challenging, primarily because of the poor self-healing capacity of articular cartilage. Gene therapy approaches have gained considerable attention, but, depending on the vector system used, they can lead to either limited or unrestrained gene expression, and therefore regulation of gene expression is necessary. This study was undertaken to construct an efficient tetracycline (Tet)-regulated, lentivirally mediated system for the expression of growth factor...     »
Journal title abbreviation:
Arthritis Rheum
Year:
2010
Journal volume:
62
Journal issue:
7
Pages contribution:
2037-46
Language:
eng
Fulltext / DOI:
doi:10.1002/art.27461
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20309869
Print-ISSN:
0004-3591
TUM Institution:
Fachgebiet Sportorthopädie (Prof. Imhoff); Institut für Experimentelle Onkologie und Therapieforschung
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