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Titel:

A functional GNAQ promoter haplotype is associated with altered Gq expression and with insulin resistance and obesity in women with polycystic ovary syndrome.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Klenke, S; Tan, S; Hahn, S; Mann, K; Hauner, H; Manthey, I; Peters, J; Siffert, W; Frey, UH
Abstract:
The G-protein Gq, encoded by GNAQ, is involved in glucose metabolism. The GNAQ promoter harbours three polymorphisms. The TT(-695/-694)GC polymorphism was already shown to affect Gq transcription. Accordingly, we (i) characterized the GNAQ promoter polymorphisms G(-173)A and G(-168)A, (ii) investigated potential influences upon the TT(-695/-694)GC polymorphism and (iii) studied the associations with metabolic abnormalities in polycystic ovary syndrome (PCOS).Characterization of the polymorphisms...     »
Zeitschriftentitel:
Pharmacogenet Genomics
Jahr:
2010
Band / Volume:
20
Heft / Issue:
8
Seitenangaben Beitrag:
476-84
Sprache:
eng
Volltext / DOI:
doi:10.1097/FPC.0b013e32833b7497
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20562673
Print-ISSN:
1744-6872
TUM Einrichtung:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin
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