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Titel:

Common variants in KCNN3 are associated with lone atrial fibrillation.

Dokumenttyp:
Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Ellinor, PT; Lunetta, KL; Glazer, NL; Pfeufer, A; Alonso, A; Chung, MK; Sinner, MF; de Bakker, PI; Mueller, M; Lubitz, SA; Fox, E; Darbar, D; Smith, NL; Smith, JD; Schnabel, RB; Soliman, EZ; Rice, KM; Van Wagoner, DR; Beckmann, BM; van Noord, C; Wang, K; Ehret, GB; Rotter, JI; Hazen, SL; Steinbeck, G; Smith, AV; Launer, LJ; Harris, TB; Makino, S; Nelis, M; Milan, DJ; Perz, S; Esko, T; Köttgen, A; Moebus, S; Newton-Cheh, C; Li, M; Möhlenkamp, S; Wang, TJ; Kao, WH; Vasan, RS; Nöthen, MM; MacRae, C...     »
Abstract:
Atrial fibrillation (AF) is the most common sustained arrhythmia. Previous studies have identified several genetic loci associated with typical AF. We sought to identify common genetic variants underlying lone AF. This condition affects a subset of individuals without overt heart disease and with an increased heritability of AF. We report a meta-analysis of genome-wide association studies conducted using 1,335 individuals with lone AF (cases) and 12,844 unaffected individuals (referents). Cases...     »
Zeitschriftentitel:
Nat Genet
Jahr:
2010
Band / Volume:
42
Heft / Issue:
3
Seitenangaben Beitrag:
240-4
Sprache:
eng
Volltext / DOI:
doi:10.1038/ng.537
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20173747
Print-ISSN:
1061-4036
TUM Einrichtung:
Institut für Humangenetik
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