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Title:

Risk gene variants for nicotine dependence in the CHRNA5-CHRNA3-CHRNB4 cluster are associated with cognitive performance.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Winterer, G; Mittelstrass, K; Giegling, I; Lamina, C; Fehr, C; Brenner, H; Breitling, LP; Nitz, B; Raum, E; Muller, H; Gallinat, J; Gal, A; Heim, K; Prokisch, H; Meitinger, T; Hartmann, AM; Möller, HJ; Gieger, C; Wichmann, HE; Illig, T; Dahmen, N; Rujescu, D
Abstract:
Recent studies strongly support an association of the nicotinic acetylcholine receptor gene cluster CHRNA5-CHRNA3-CHRNB4 with nicotine dependence (ND). However, the precise genotype-phenotype relationship is still unknown. Clinical and epidemiological data on smoking behavior raise the possibility that the relevant gene variants may indirectly contribute to the development of ND by affecting cognitive performance in some smokers who consume nicotine for reasons of "cognition enhancement." Here,...     »
Journal title abbreviation:
Am J Med Genet B Neuropsychiatr Genet
Year:
2010
Journal volume:
153B
Journal issue:
8
Pages contribution:
1448-58
Language:
eng
Fulltext / DOI:
doi:10.1002/ajmg.b.31126
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20886544
Print-ISSN:
1552-4841
TUM Institution:
Institut für Humangenetik
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