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Title:

Common variants in KCNN3 are associated with lone atrial fibrillation.

Document type:
Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Ellinor, PT; Lunetta, KL; Glazer, NL; Pfeufer, A; Alonso, A; Chung, MK; Sinner, MF; de Bakker, PI; Mueller, M; Lubitz, SA; Fox, E; Darbar, D; Smith, NL; Smith, JD; Schnabel, RB; Soliman, EZ; Rice, KM; Van Wagoner, DR; Beckmann, BM; van Noord, C; Wang, K; Ehret, GB; Rotter, JI; Hazen, SL; Steinbeck, G; Smith, AV; Launer, LJ; Harris, TB; Makino, S; Nelis, M; Milan, DJ; Perz, S; Esko, T; Köttgen, A; Moebus, S; Newton-Cheh, C; Li, M; Möhlenkamp, S; Wang, TJ; Kao, WH; Vasan, RS; Nöthen, MM; MacRae, C...     »
Abstract:
Atrial fibrillation (AF) is the most common sustained arrhythmia. Previous studies have identified several genetic loci associated with typical AF. We sought to identify common genetic variants underlying lone AF. This condition affects a subset of individuals without overt heart disease and with an increased heritability of AF. We report a meta-analysis of genome-wide association studies conducted using 1,335 individuals with lone AF (cases) and 12,844 unaffected individuals (referents). Cases...     »
Journal title abbreviation:
Nat Genet
Year:
2010
Journal volume:
42
Journal issue:
3
Pages contribution:
240-4
Language:
eng
Fulltext / DOI:
doi:10.1038/ng.537
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20173747
Print-ISSN:
1061-4036
TUM Institution:
Institut für Humangenetik
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