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- Dokumenttyp:
- Journal Article; Research Support, Non-U.S. Gov't
- Autor(en):
- Mangold, E; Ludwig, KU; Birnbaum, S; Baluardo, C; Ferrian, M; Herms, S; Reutter, H; de Assis, NA; Chawa, TA; Mattheisen, M; Steffens, M; Barth, S; Kluck, N; Paul, A; Becker, J; Lauster, C; Schmidt, G; Braumann, B; Scheer, M; Reich, RH; Hemprich, A; Pötzsch, S; Blaumeiser, B; Moebus, S; Krawczak, M; Schreiber, S; Meitinger, T; Wichmann, HE; Steegers-Theunissen, RP; Kramer, FJ; Cichon, S; Propping, P; Wienker, TF; Knapp, M; Rubini, M; Mossey, PA; Hoffmann, P; Nöthen, MM
- Titel:
- Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate.
- Abstract:
- We conducted a genome-wide association study for nonsyndromic cleft lip with or without cleft palate (NSCL/P) in 401 affected individuals and 1,323 controls, with replication in an independent sample of 793 NSCL/P triads. We report two new loci associated with NSCL/P at 17q22 (rs227731, combined P = 1.07 x 10(-8), relative risk in homozygotes = 1.84, 95% CI 1.34-2.53) and 10q25.3 (rs7078160, combined P = 1.92 x 10(-8), relative risk in homozygotes = 2.17, 95% CI 1.32-3.56).
- Zeitschriftentitel:
- Nat Genet
- Jahr:
- 2010
- Band / Volume:
- 42
- Heft / Issue:
- 1
- Seitenangaben Beitrag:
- 24-6
- Sprache:
- eng
- Volltext / DOI:
- doi:10.1038/ng.506
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/20023658
- Print-ISSN:
- 1061-4036
- TUM Einrichtung:
- Institut für Humangenetik
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