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Titel:

Tracking stem cell differentiation in the setting of automated optogenetic stimulation.

Dokumenttyp:
journal article
Autor(en):
Stroh, A; Tsai, HC; Ping Wang, L; Zhang, F; Kressel, J; Aravanis, A; Santhanam, N; Deisseroth, K; Konnerth, A; Schneider, MB
Abstract:
Membrane depolarization has been shown to play an important role in the neural differentiation of stem cells as well as in the survival and function of mature neurons. Here we introduce a microbial opsin into embryonic stem cells and develop optogenetic technology for stem cell engineering applications, with an automated system for noninvasive modulation of embryonic stem cell differentiation employing fast optogenetic control of ion flux. Mouse embryonic stem cells (ESCs) were stably transduced...     »
Zeitschriftentitel:
Stem Cells
Jahr:
2010
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21089034
Print-ISSN:
1066-5099
TUM Einrichtung:
Abteilung für Neuroradiologie ; Institut für Neurowissenschaften
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