Benutzer: Gast  Login
Titel:

Antifungal therapy with itraconazole impairs the anti-lymphoma effects of rituximab by inhibiting recruitment of CD20 to cell surface lipid rafts.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Ringshausen, I; Feuerstacke, Y; Krainz, P; den Hollander, J; Hermann, K; Buck, A; Peschel, C; Meyer Zum Bueschenfelde, C
Abstract:
Immunotherapy with rituximab alone or in conjunction with chemotherapy has significantly improved the treatment outcome of B-cell lymphoma patients. Nevertheless, a subpopulation of patients does not respond to rituximab. The reason for treatment failure as well as the exact mechanism of action is still uncertain. The function of rituximab has long been associated with the partitioning of CD20 molecules to membrane microdomains. Here, we show that concomitant antifungal treatment with itraconazo...     »
Zeitschriftentitel:
Cancer Res
Jahr:
2010
Band / Volume:
70
Heft / Issue:
11
Seitenangaben Beitrag:
4292-6
Sprache:
eng
Volltext / DOI:
doi:10.1158/0008-5472.CAN-10-0259
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20460536
Print-ISSN:
0008-5472
TUM Einrichtung:
Fachgebiet Neuroradiologie (Prof. Zimmer); III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Klinik und Poliklinik für Nuklearmedizin
 BibTeX