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Titel:

Micro-RNA-155 inhibits IFN-gamma signaling in CD4+ T cells.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Banerjee, A; Schambach, F; DeJong, CS; Hammond, SM; Reiner, SL
Abstract:
Micro-RNA (miR) are increasingly recognized as critical regulators of tissue-specific patterns of gene expression. CD4+ T cells lacking miR-155, for example, exhibit bias towards Th2 differentiation, indicating that the absence of individual miR could alter CD4+ T-cell differentiation. We now show that miR-155 is induced upon T-cell activation and that it promotes Th1 differentiation when over-expressed in activated CD4+ T cells. Antagonism of miR-155 leads to induction of IFN-gamma receptor alp...     »
Zeitschriftentitel:
Eur J Immunol
Jahr:
2010
Band / Volume:
40
Heft / Issue:
1
Seitenangaben Beitrag:
225-31
Sprache:
eng
Volltext / DOI:
doi:10.1002/eji.200939381
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19877012
Print-ISSN:
0014-2980
TUM Einrichtung:
Fachgebiet Neuroradiologie (Prof. Zimmer)
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