Tool use engages a left hemispheric network including frontal, temporal and parietal regions. Patients with left brain lesions (LBD patients) exhibit deficits when demonstrating use of a single tool (apraxia). When attempting to use a tool, some apraxic patients show errors in the preceding grasping movement. Forty-two LBD patients and 18 healthy controls grasped individual tools and demonstrated their typical use. For patients with a tool use impairment (22), lesion analysis revealed a large area of overlap in the left hemisphere, mainly in the supramarginal gyrus (SMG). For patients with erroneous grasping (12), the lesion overlay showed overlaps in the left frontal and parietal cortices, especially in the inferior frontal gyrus (IFG) and the angular gyrus (ANG). However, contrasting lesions associated with impaired grasping versus tool use impairments reveal little overlap, limited to the inferior parietal cortex. Presumably the left IFG is involved in selection processes in the context of tool use, such as choosing a functional or non-functional grasping movement depending on the task and the online information about the tool's structure and orientation. The ANG might provide this grasp related information, which is relevant for the specific action. The contribution of the SMG to tool use involves more general principals, such as integrating online and learned tool use information into the action plan for the use movement.     «

Tool use engages a left hemispheric network including frontal, temporal and parietal regions. Patients with left brain lesions (LBD patients) exhibit deficits when demonstrating use of a single tool (apraxia). When attempting to use a tool, some apraxic patients show errors in the preceding grasping movement. Forty-two LBD patients and 18 healthy controls grasped individual tools and demonstrated their typical use. For patients with a tool use impairment (22), lesion analysis revealed a large ar...     »