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Title:

Common variants at 10 genomic loci influence hemoglobin A?(C) levels via glycemic and nonglycemic pathways.

Document type:
Journal Article; nicht gelistet
Author(s):
Soranzo, N; Sanna, S; Wheeler, E; Gieger, C; Radke, D; Dupuis, J; Bouatia-Naji, N; Langenberg, C; Prokopenko, I; Stolerman, E; Sandhu, MS; Heeney, MM; Devaney, JM; Reilly, MP; Ricketts, SL; Stewart, AF; Voight, BF; Willenborg, C; Wright, B; Altshuler, D; Arking, D; Balkau, B; Barnes, D; Boerwinkle, E; Böhm, B; Bonnefond, A; Bonnycastle, LL; Boomsma, DI; Bornstein, SR; Böttcher, Y; Bumpstead, S; Burnett-Miller, MS; Campbell, H; Cao, A; Chambers, J; Clark, R; Collins, FS; Coresh, J; de Geus, EJ; D...     »
Abstract:
Glycated hemoglobin (HbA?(c)), used to monitor and diagnose diabetes, is influenced by average glycemia over a 2- to 3-month period. Genetic factors affecting expression, turnover, and abnormal glycation of hemoglobin could also be associated with increased levels of HbA?(c). We aimed to identify such genetic factors and investigate the extent to which they influence diabetes classification based on HbA?(c) levels.We studied associations with HbA?(c) in up to 46,368 nondiabetic adults of Europea...     »
Journal title abbreviation:
Diabetes
Year:
2010
Journal volume:
59
Journal issue:
12
Pages contribution:
3229-39
Language:
eng
Fulltext / DOI:
doi:10.2337/db10-0502
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20858683
Print-ISSN:
0012-1797
TUM Institution:
Neurologische Klinik und Poliklinik
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