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Title:

The mu-opioid receptor agonist remifentanil induces acute dysphoria irrespective of its analgesic properties.

Document type:
Journal Article; Article
Author(s):
Wagner, KJ; Valet, M; Kochs, EF; Kriner, M; Tölle, TR; Sprenger, T
Abstract:
Mu-opioidergic agonists are believed to induce euphoria, whereas kappa-agonists are thought to lead to dysphoria. Our study investigated mood effects of remifentanil, a mu-receptor opioid agonist, in healthy male volunteers. Moreover, we examined interactions between mood and pain. Three conditions were investigated in 21 volunteers: saline, 0.05 and 0.15 microg kg(-1) min(- 1) remifentanil. Each condition was investigated during non-painful heat and during painful heat stimulation. Mood was mea...     »
Journal title abbreviation:
J Psychopharmacol
Year:
2010
Journal volume:
24
Journal issue:
3
Pages contribution:
355-61
Language:
eng
Fulltext / DOI:
doi:10.1177/0269881108095811
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18801832
Print-ISSN:
0269-8811
TUM Institution:
Institut für Medizinische Statistik und Epidemiologie; Klinik für Anästhesiologie (DHM); Neurologische Klinik und Poliklinik
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