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Titel:

Apixaban for reduction in stroke and other ThromboemboLic events in atrial fibrillation (ARISTOTLE) trial: design and rationale.

Dokumenttyp:
Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Article
Autor(en):
Lopes, RD; Alexander, JH; Al-Khatib, SM; Ansell, J; Diaz, R; Easton, JD; Gersh, BJ; Granger, CB; Hanna, M; Horowitz, J; Hylek, EM; McMurray, JJ; Verheugt, FW; Wallentin, L
Abstract:
Atrial fibrillation (AF) is associated with increased risk of stroke that can be attenuated with vitamin K antagonists (VKAs). Vitamin K antagonist use is limited, in part, by the high incidence of complications when patients' international normalized ratios (INRs) deviate from the target range. The primary objective of ARISTOTLE is to determine if the factor Xa inhibitor, apixaban, is noninferior to warfarin at reducing the combined endpoint of stroke (ischemic or hemorrhagic) and systemic embo...     »
Zeitschriftentitel:
Am Heart J
Jahr:
2010
Band / Volume:
159
Heft / Issue:
3
Seitenangaben Beitrag:
331-9
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.ahj.2009.07.035
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20211292
Print-ISSN:
0002-8703
TUM Einrichtung:
Neurologische Klinik und Poliklinik
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