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Titel:

Cooperation of B cells and T cells in the pathogenesis of multiple sclerosis.

Dokumenttyp:
Journal Article
Autor(en):
Weber, MS; Hemmer, B
Abstract:
B cells and T cells are two major players in the pathogenesis of multiple sclerosis (MS) and cooperate at various check points. B cells, besides serving as a source for antibody-secreting plasma cells, are efficient antigen presenting cells for processing of intact myelin antigen and subsequent activation and pro-inflammatory differentiation of T cells. This notion is supported by the immediate clinical benefit of therapeutic B cell depletion in MS, presumably abrogating development of encephali...     »
Zeitschriftentitel:
Results Probl Cell Differ
Jahr:
2010
Band / Volume:
51
Seitenangaben Beitrag:
115-26
Sprache:
eng
Volltext / DOI:
doi:10.1007/400_2009_21
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19582406
Print-ISSN:
0080-1844
TUM Einrichtung:
Neurologische Klinik und Poliklinik
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