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Document type:
Journal Article; Research Support, Non-U.S. Gov't; Review 
Author(s):
Poeck, H; Ruland, J 
Title:
ITAM receptor signaling and the NLRP3 inflammasome in antifungal immunity. 
Abstract:
INTRODUCTION: Infections with fungi can cause systemic life-threatening diseases in immunocompromised individuals like cancer or AIDS patients. Recent work has uncovered essential roles for C-type lectin pattern recognition receptors, spleen tyrosine kinase (SYK) and the cytosolic NLRP3 inflammasome in innate antifungal immunity. Upon fungal infection, SYK is activated by several ITAM-containing or ITAM-coupled C-type lectin receptors on myeloid cells leading to the production of pro-inflammator...    »
 
Journal title abbreviation:
J Clin Immunol 
Year:
2010 
Journal volume:
30 
Journal issue:
Pages contribution:
496-501 
Language:
eng 
Print-ISSN:
0271-9142 
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Roman Herzog Comprehensive Cancer Center