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Titel:

Recruitment of PKC-betaII to lipid rafts mediates apoptosis-resistance in chronic lymphocytic leukemia expressing ZAP-70.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
zum Büschenfelde, CM; Wagner, M; Lutzny, G; Oelsner, M; Feuerstacke, Y; Decker, T; Bogner, C; Peschel, C; Ringshausen, I
Abstract:
ZAP-70 is a key signaling molecule in T cells. It couples the antigen-activated T-cell receptor to downstream signaling pathways. Its expression in leukemic B-cells derived from a subgroup of patients with chronic lymphocytic leukemia (CLL) is associated with an aggressive course of the disease. However, its implication for the pathogenesis of aggressive CLL is still unclear. In this study, we show that the expression of ZAP-70 enhances the signals associated with the B-cell receptor, recruiting...     »
Zeitschriftentitel:
Leukemia
Jahr:
2010
Band / Volume:
24
Heft / Issue:
1
Seitenangaben Beitrag:
141-52
Sprache:
eng
Volltext / DOI:
doi:10.1038/leu.2009.216
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19907441
Print-ISSN:
0887-6924
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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