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Title:

C/EBPbeta expression in ALK-positive anaplastic large cell lymphomas is required for cell proliferation and is induced by the STAT3 signaling pathway.

Document type:
Journal Article
Author(s):
Anastasov, N; Bonzheim, I; Rudelius, M; Klier, M; Dau, T; Angermeier, D; Duyster, J; Pittaluga, S; Fend, F; Raffeld, M; Quintanilla-Martinez, L
Abstract:
BACKGROUND: Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma is characterized by the t(2; 5) chromosomal translocation, resulting in the expression of a fusion protein formed of nucleophosmin (NPM) and ALK. Recently, we reported the abnormal expression of the transcription factor CCAAT/enhancer binding protein-beta (C/EBPbeta) in ALK-positive anaplastic large cell lymphomas, and demonstrated its dependence on NPM-ALK activity. DESIGN AND METHODS: In this study, the role o...     »
Journal title abbreviation:
Haematologica
Year:
2010
Journal volume:
95
Journal issue:
5
Pages contribution:
760-7
Language:
eng
Fulltext / DOI:
doi:10.3324/haematol.2009.014050
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20015877
Print-ISSN:
0390-6078
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Allgemeine Pathologie und Pathologische Anatomie
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