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Title:

SYK kinase signaling and the NLRP3 inflammasome in antifungal immunity.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Review
Author(s):
Poeck, H; Ruland, J
Abstract:
Host protection against fungi depends on intact innate and adaptive immune responses. Consistently, fungal infections can cause systemic life-threatening diseases in immunocomprimised individuals, suffering e.g. from cancer or AIDS. Recent work has uncovered essential roles for the spleen tyrosine kinase (SYK) and the cytosolic NLRP3 inflammasome for Interleukin-1beta (IL-1beta) production in innate antifungal immunity. Upon fungal infection, SYK is activated by several C-type lectin pattern rec...     »
Journal title abbreviation:
J Mol Med
Year:
2010
Journal volume:
88
Journal issue:
8
Pages contribution:
745-52
Language:
eng
Fulltext / DOI:
doi:10.1007/s00109-010-0631-4
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20401456
Print-ISSN:
0946-2716
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Roman Herzog Comprehensive Cancer Center
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