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Title:

The SYK tyrosine kinase: a crucial player in diverse biological functions.

Document type:
journal article
Author(s):
Mócsai, A; Ruland, J; Tybulewicz, VL
Abstract:
Spleen tyrosine kinase (SYK) is known to have a crucial role in adaptive immune receptor signalling. However, recent reports indicate that SYK also mediates other, unexpectedly diverse biological functions, including cellular adhesion, innate immune recognition, osteoclast maturation, platelet activation and vascular development. SYK is activated by C-type lectins and integrins, and activates new targets, including the CARD9-BCL-10-MALT1 pathway and the NLRP3 inflammasome. Studies using Drosophi...     »
Journal title abbreviation:
Nat Rev Immunol
Year:
2010
Journal volume:
10
Journal issue:
6
Pages contribution:
387-402
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20467426
Print-ISSN:
1474-1733
TUM Institution:
III. Medizinische Klinik und Poliklinik
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