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Title:

ITAM receptor signaling and the NLRP3 inflammasome in antifungal immunity.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Review
Author(s):
Poeck, H; Ruland, J
Abstract:
INTRODUCTION: Infections with fungi can cause systemic life-threatening diseases in immunocompromised individuals like cancer or AIDS patients. Recent work has uncovered essential roles for C-type lectin pattern recognition receptors, spleen tyrosine kinase (SYK) and the cytosolic NLRP3 inflammasome in innate antifungal immunity. Upon fungal infection, SYK is activated by several ITAM-containing or ITAM-coupled C-type lectin receptors on myeloid cells leading to the production of pro-inflammator...     »
Journal title abbreviation:
J Clin Immunol
Year:
2010
Journal volume:
30
Journal issue:
4
Pages contribution:
496-501
Language:
eng
Fulltext / DOI:
doi:10.1007/s10875-010-9385-6
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20401526
Print-ISSN:
0271-9142
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Roman Herzog Comprehensive Cancer Center
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