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Titel:

ITAM receptor signaling and the NLRP3 inflammasome in antifungal immunity.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Review
Autor(en):
Poeck, H; Ruland, J
Abstract:
INTRODUCTION: Infections with fungi can cause systemic life-threatening diseases in immunocompromised individuals like cancer or AIDS patients. Recent work has uncovered essential roles for C-type lectin pattern recognition receptors, spleen tyrosine kinase (SYK) and the cytosolic NLRP3 inflammasome in innate antifungal immunity. Upon fungal infection, SYK is activated by several ITAM-containing or ITAM-coupled C-type lectin receptors on myeloid cells leading to the production of pro-inflammator...     »
Zeitschriftentitel:
J Clin Immunol
Jahr:
2010
Band / Volume:
30
Heft / Issue:
4
Seitenangaben Beitrag:
496-501
Sprache:
eng
Volltext / DOI:
doi:10.1007/s10875-010-9385-6
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20401526
Print-ISSN:
0271-9142
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Roman Herzog Comprehensive Cancer Center
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