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Titel:

The adaptor molecule CARD9 is essential for tuberculosis control.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Dorhoi, A; Desel, C; Yeremeev, V; Pradl, L; Brinkmann, V; Mollenkopf, HJ; Hanke, K; Gross, O; Ruland, J; Kaufmann, SH
Abstract:
The cross talk between host and pathogen starts with recognition of bacterial signatures through pattern recognition receptors (PRRs), which mobilize downstream signaling cascades. We investigated the role of the cytosolic adaptor caspase recruitment domain family, member 9 (CARD9) in tuberculosis. This adaptor was critical for full activation of innate immunity by converging signals downstream of multiple PRRs. Card9(-/-) mice succumbed early after aerosol infection, with higher mycobacterial b...     »
Zeitschriftentitel:
J Exp Med
Jahr:
2010
Band / Volume:
207
Heft / Issue:
4
Seitenangaben Beitrag:
777-92
Sprache:
eng
Volltext / DOI:
doi:10.1084/jem.20090067
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20351059
Print-ISSN:
0022-1007
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Roman Herzog Comprehensive Cancer Center
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