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Title:

Classification of HER2/neu Status in Gastric Cancer Using a Breast-Cancer Derived Proteome Classifier.

Document type:
Journal Article; Article
Author(s):
Balluff, B; Elsner, M; Kowarsch, A; Rauser, S; Meding, S; Schuhmacher, C; Feith, M; Herrmann, K; Ro?cken, C; Schmid, RM; Ho?fler, H; Walch, A; Ebert, MP
Abstract:
HER2-testing in breast and gastric cancers is mandatory for the treatment with trastuzumab. We hypothesized that imaging mass spectrometry (IMS) of breast cancers may be useful for generating a classifier that may determine HER2-status in other cancer entities irrespective of primary tumor site. A total of 107 breast (n = 48) and gastric (n = 59) cryo tissue samples was analyzed by IMS (HER2 was present in 29 cases). The obtained proteomic profiles were used to create HER2 prediction models usin...     »
Journal title abbreviation:
J Proteome Res
Year:
2010
Journal volume:
9
Journal issue:
12
Pages contribution:
6317-6322
Language:
eng
Fulltext / DOI:
doi:10.1021/pr100573s
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21058730
Print-ISSN:
1535-3893
TUM Institution:
Chirurgische Klinik und Poliklinik; II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für Nuklearmedizin
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