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Titel:

Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state.

Dokumenttyp:
Journal Article
Autor(en):
den Hollander, J; Rimpi, S; Doherty, JR; Rudelius, M; Buck, A; Hoellein, A; Kremer, M; Graf, N; Scheerer, M; Hall, MA; Goga, A; von Bubnoff, N; Duyster, J; Peschel, C; Cleveland, JL; Nilsson, JA; Keller, U
Abstract:
Myc oncoproteins promote continuous cell growth, in part by controlling the transcription of key cell cycle regulators. Here, we report that c-Myc regulates the expression of Aurora A and B kinases (Aurka and Aurkb), and that Aurka and Aurkb transcripts and protein levels are highly elevated in Myc-driven B-cell lymphomas in both mice and humans. The induction of Aurka by Myc is transcriptional and is directly mediated via E-boxes, whereas Aurkb is regulated indirectly. Blocking Aurka/b kinase a...     »
Zeitschriftentitel:
Blood
Jahr:
2010
Band / Volume:
116
Heft / Issue:
9
Seitenangaben Beitrag:
1498-505
Sprache:
eng
Volltext / DOI:
doi:10.1182/blood-2009-11-251074
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20519624
Print-ISSN:
0006-4971
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für Nuklearmedizin
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