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Titel:

Classification of HER2/neu Status in Gastric Cancer Using a Breast-Cancer Derived Proteome Classifier.

Dokumenttyp:
Journal Article; Article
Autor(en):
Balluff, B; Elsner, M; Kowarsch, A; Rauser, S; Meding, S; Schuhmacher, C; Feith, M; Herrmann, K; Ro?cken, C; Schmid, RM; Ho?fler, H; Walch, A; Ebert, MP
Abstract:
HER2-testing in breast and gastric cancers is mandatory for the treatment with trastuzumab. We hypothesized that imaging mass spectrometry (IMS) of breast cancers may be useful for generating a classifier that may determine HER2-status in other cancer entities irrespective of primary tumor site. A total of 107 breast (n = 48) and gastric (n = 59) cryo tissue samples was analyzed by IMS (HER2 was present in 29 cases). The obtained proteomic profiles were used to create HER2 prediction models usin...     »
Zeitschriftentitel:
J Proteome Res
Jahr:
2010
Band / Volume:
9
Heft / Issue:
12
Seitenangaben Beitrag:
6317-6322
Sprache:
eng
Volltext / DOI:
doi:10.1021/pr100573s
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21058730
Print-ISSN:
1535-3893
TUM Einrichtung:
Chirurgische Klinik und Poliklinik; II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für Nuklearmedizin
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