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Title:

A 3'-untranslated region variant is associated with impaired expression of CD226 in T and natural killer T cells and is associated with susceptibility to systemic lupus erythematosus.

Document type:
journal article
Author(s):
Löfgren, SE; Delgado-Vega, AM; Gallant, CJ; Sánchez, E; Frostegård, J; Truedsson, L; de Ramón Garrido, E; Sabio, JM; González-Escribano, MF; Pons-Estel, BA; D'Alfonso, S; Witte, T; Lauwerys, BR; Endreffy, E; Kovács, L; Vasconcelos, C; Martins da Silva, B; Martín, J; Alarcón-Riquelme, ME; Kozyrev, SV
Abstract:
Costimulatory receptor CD226 plays an important role in T cell activation, differentiation, and cytotoxicity. This study was undertaken to investigate the genetic association of CD226 with susceptibility to systemic lupus erythematosus (SLE) and to assess the functional implications of this association.Twelve tag single-nucleotide polymorphisms (SNPs) in CD226 were typed in 1,163 SLE patients and 1,482 healthy control subjects from Europe or of European ancestry. Analyses of association were per...     »
Journal title abbreviation:
Arthritis Rheum
Year:
2010
Journal volume:
62
Journal issue:
11
Pages contribution:
3404-14
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20669283
Print-ISSN:
0004-3591
TUM Institution:
Klinik und Poliklinik für Plastische Chirurgie und Handchirurgie
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