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Title:

Head circumference, atrophy, and cognition: implications for brain reserve in Alzheimer disease.

Document type:
Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Article
Author(s):
Perneczky, R; Wagenpfeil, S; Lunetta, KL; Cupples, LA; Green, RC; Decarli, C; Farrer, LA; Kurz, A
Abstract:
BACKGROUND: Clinical and epidemiologic studies suggest that patients with Alzheimer disease (AD) with larger head circumference have better cognitive performance at the same level of brain pathology than subjects with smaller head circumference. METHODS: A total of 270 patients with AD participating in the Multi-Institutional Research in Alzheimer's Genetic Epidemiology (MIRAGE) study underwent cognitive testing, APOE genotyping, and MRI of the brain in a cross-sectional study. Linear regression...     »
Journal title abbreviation:
Neurology
Year:
2010
Journal volume:
75
Journal issue:
2
Pages contribution:
137-42
Language:
eng
Fulltext / DOI:
doi:10.1212/WNL.0b013e3181e7ca97
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20625166
Print-ISSN:
0028-3878
TUM Institution:
Institut für Medizinische Statistik und Epidemiologie; Klinik und Poliklinik für Psychiatrie und Psychotherapie
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