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Title:

Immunohistochemical detection of receptor tyrosine kinases c-kit, EGF-R, and PDGF-R in colorectal adenocarcinomas.

Document type:
Journal Article; Article
Author(s):
Friederichs, J; von Weyhern, CW; Rosenberg, R; Doll, D; Busch, R; Lordick, F; Siewert, JR; Sarbia, M
Abstract:
PURPOSE: The selective inhibition of tyrosine kinases is a promising strategy in the treatment of several human malignancies. This study aimed to clarify expression patterns of therapeutically addressable receptor tyrosine kinases in colorectal cancer. MATERIALS AND METHODS: In this study, we used tissue arrays to analyze 263 specimen of colorectal carcinoma for the expression of the tyrosine kinases c-kit (CD117), epidermal growth factor receptor (EGF-R), and platelet-derived growth factor rece...     »
Journal title abbreviation:
Langenbecks Arch Surg
Year:
2010
Journal volume:
395
Journal issue:
4
Pages contribution:
373-9
Language:
eng
Fulltext / DOI:
doi:10.1007/s00423-009-0478-8
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19280218
Print-ISSN:
1435-2443
TUM Institution:
Chirurgische Klinik und Poliklinik; Institut für Medizinische Statistik und Epidemiologie
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