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Title:

An oncogenic role of eIF3e/INT6 in human breast cancer.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Grzmil, M; Rzymski, T; Milani, M; Harris, AL; Capper, RG; Saunders, NJ; Salhan, A; Ragoussis, J; Norbury, CJ
Abstract:
Altered expression of the eukaryotic translation initiation factor 3 (eIF3) subunit eIF3e/INT6 has been described in various types of human cancer, but the nature of its involvement in tumorigenesis is not yet clear. Using immunohistochemical analysis of 81 primary breast cancers, we found that high tumor grade correlated significantly with elevated cytoplasmic eIF3e level in epithelial tumor cells. Analysis of protein synthesis after siRNA-mediated knockdown in breast cancer cell lines indicate...     »
Journal title abbreviation:
Oncogene
Year:
2010
Journal volume:
29
Journal issue:
28
Pages contribution:
4080-9
Language:
eng
Fulltext / DOI:
doi:10.1038/onc.2010.152
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20453879
Print-ISSN:
0950-9232
TUM Institution:
Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess)
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